S89687 |
SEC inhibitor KL-2 |
源叶(MedMol) | 98% |
- 产品描述: SEC inhibitor KL-2 (KL-2), a peptidomimetic lead compound, is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. SEC inhibitor KL-2 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with a Ki of 1.50 μM
- 靶点: SEC
- 参考文献:
1. Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779.
- 溶解性: soluble in DMSO
- 保存条件: -20℃
- 配置溶液浓度参考:
1mg 5mg 10mg 1 mM 2.996 ml 14.982 ml 29.963 ml 5 mM 0.599 ml 2.996 ml 5.993 ml 10 mM 0.3 ml 1.498 ml 2.996 ml 50 mM 0.06 ml 0.3 ml 0.599 ml
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质量 (mg) = 浓度 (mM) x 体积 (mL) x 分子量 (g/mol)